Publications
​現在作成中です

S. Tanaka, K. Fujita, Y. Yamamoto, F. A. Md Zulkifie, T. Suzuki, M. Naito, U. Chung, T. Katashima*
Release mechanism of micrometer-scale particles from transient networks with well-controlled structures. Polym. J., in press (2025)
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H. Chang, F. Aulia, R. Kamegawa, N. Qiao, M. Hori, S. Ogura, C. Y. J. Lau, N. Yamada, K. Taniwaki, M. Naito*, H. J. Kim, K. Miyata*
Silica-coated polyion complexes for enhanced pulmonary messenger RNA delivery with optimized silica layer stability. J. Control. Release, 386, 114136 (2025)
 

H. Chaya, M. Naito, K. Toh, K. Taniwaki, Y. Kinoshita, S. Fukushima, K. Minegishi, Y. Aoki, T. Nagata, T. Yokota, K. Kataoka, K. Miyata*
Enhanced accumulation of heteroduplex oligonucleotides in skeletal muscles by single oligonucleotide-loaded unit polyion complexes. ACS Omega, 10(31) 34363–34371 (2025)
 

N. Qiao, M. Hori*, M. Naito, H. Chang, S. Ogura, M. Suzuki, T. Kimura, S. Fukushima, H. J. Kim, S. Uchida*, K. Miyata*
Increasing polycation hydrophobicity in mRNA polyplex vaccines enhances the efficacy of humoral and cellular immunity induction. Biomaterials, 324, 123515 (2026)
 

Y. Yamamoto, M. LeFevre, Y. Yamagata, M. Araida, T. Sato, M. Naito, U. Chung. T. Katashima*
Investigating the impact of strand length distribution on nonlinear relaxation in transient networks. Polymer, 334, 128710 (2025)
 

C. Y. J. Lau*, H. Kinoh, X. Liu, J. Feng, F. Aulia, K. Taniwaki, N. Qiao, S. Ogura, M. Naito, K. Miyata*
Structurally dynamic polyplexes enhance sentinel lymph node delivery of antisense oligonucleotides to inhibit breast cancer recurrence and metastasis” J. Am. Chem. Soc., 147 (30) 26286–26297 (2025)
 

C. Wang, A. Fulati, K. Kimura, X. Li, J. J. Richardson, M. Naito, K. Miyata, T. Ichiki, H. Ejima*
Encapsulation of Small Extracellular Vesicles into Selectively Disassemblable Shells of PEGylated Metal-Phenolic Network. Adv. Healthc. Mater., 14(18) e2405188 (2025) 
 

D. Koam, H. Y. Park, D. S. Kim, H. J. Kwon, Y. Lee, K. Kim, M. Naito*, H. J. Kim*
Amphiphilic polyaspartamide derivatives with cholesterol introduction enhanced Ex vivo mRNA transfection effeciency to natural killer cells. Biomacromolecules, 26(2) 1086–1097 (2025) 
 

D. Maiti, H. Yao, J. S. An, S. Yamashita, M. Naito, K. Miyata, H. J. Kim*
Dual porphyrin-loaded scintillating nanoparticles enhanced photodynamic therapy in hypoxic cancer cells under X-ray irradiation. ChemBioChem, 26(4) e202400838 (2025)
 

K. Nakamura, S. Michida, M. Naito, U. Chung, T. Katasahima*
Relationships between dynamic heterogeneity and network topology in transient networks based on microrheological study. Polym. J., 57 427–434 (2025)
 

W. Liao, B. Cheng, C. Wang, J. J. Richardson, M. Naito, K. Miyata, H. Ejima*
Surface-initiated synergistic disassembly of metal-phenolic networks by redox and hydrolytic reactions. Chem. Mater., 36(19) 9646–9657 (2024)
 

J. Hasegawa, T. Nagata*, K. Ihara, J. Tanihata, S. Ebihara, K. Yoshida, M. Yanagidaira, M. Ohara, M. Nakayama, S. Yamamoto, T. Ishii, R. Iwata, M. Naito, K. Miyata, F. Sakaue, T. Yokota*
Heteroduplex oligonucleotide technology boosts oligonucleotide splice switching activity of morpholino oligomers in a Duchenne muscular dystrophy mouse model. Nat. Commun., 15, 7530 (2024)
 

Y. Yamamoto, Y. Yamagata, T. Sato, N. Nakamura, R. Sato, M. Naito, U. Chung, T. Katashima*
Elucidating Nonlinear stress relaxation in tetra-armed transient networks using two-dimensional rheo-optics method. ACS Macro Lett., 13(9) 1171–1178 (2024)
 

Y. Ishibashi, M. Naito*, Y. Watanuki, M. Hori, S. Ogura, K. Taniwaki, M. Cho, R. Komiya, Y. Mochida, K. Miyata
Size-dependent glioblastoma targeting by polymeric nanoruler with prolonged blood circulation” Bioconjugate Chem., 35(8) 1154–1159 (2024)
 

R. Kobayashi, M. Naito, K. Miyata, T. Sakai, U. Chung, T. Katashima*
Prediction of viscoelastic relaxation time by degradation using model transient networks. Polym. J., 56(7) 685­–691 (2024)
 

J. Yum, F. Aulia, K. Kamiya, M. Hori, N. Qiao, B. S. Kim, M. Naito, S. Ogura, T. Nagata, T. Yokota, S. Uchida, S. Obika, H. J. Kim*, K. Miyata*
Hydrophobicity tuning of cationic polyaspartamide derivatives for enhanced antisense oligonucleotide delivery. Bioconjugate Chem., 35(2) 125–131 (2024)
 

K. Morihiro*, S. Morita, J. Yum, M. Naito, K. Miyata, G. Nagae, A. Okamoto*
RNA oncological therapeutics: intracellular hairpin RNA assembly enables microRNA-triggered anticancer functionality. J. Am. Chem. Soc., 146(2) 1346–1355 (2024)
 

K. Fujiura, M. Naito, Y. Tanaka, M. Tanaka, Y. Nakanishi, H. Ejima, L. Negishi, T. Kujirai, H. Kurumizaka, S. Ohta, K. Miyata*
Development of stealth nanoparticles coated with poly(2-methoxyethyl vinyl ether) as an alternative to poly(ethylene glycol). J. Appl. Polym. Sci., 141(11) e55044 (2024)
 

D. Maiti, H. Yu, Y. Mochida, S. Won, S. Yamashita, M. Naito, K. Miyata, H. J. Kim*
Terbium-rose bengal coordination nanocrystals-induced ROS production under low-dose X-rays in cultured cancer cells for photodynamic therapy. ACS Appl. Bio Mater., 6 (6) 2505–2513 (2023)
 

J. Kim, S. Ishikawa*, M. Naito, X. Li, U. Chung, T. Sakai*
Miscibility and ternary diagram of aqueous poly(vinyl alcohol)s with different degrees of saponification” Sci. Rep., 13 (1), 8791 (2023)
 

M. Kato, S. Ishikawa, Q. Shen, Z. Du, T. Katashima, M. Naito, T. Numata, M. Okazaki*, T. Sakai*
In situ-formable, dynamic crosslinked poly(ethylene glycol) carrier for localized adeno-associated virus infection and reduced off-target effects. Commun. Biol., 6 (1), 508 (2023)
 

S. Ishikawa*, M. Kato, J. Si, L. Chenyu, K. Kimura, T. Katashima, M. Naito, M. Kurita, T. Sakai*
Molecular Weight-Dependent Diffusion, Biodistribution, and Clearance Behavior of Tetra-Armed Poly(ethylene glycol) Subcutaneously Injected into the Back of Mice. ACS Macro Lett., 12 (4) 510–517 (2023)
 

T. Katashima*, R. Kobayashi, S. Ishikawa, M. Naito, K. Miyata, U. Chung, T. Sakai.
Decoupling between translational diffusion and viscoelasticity in transient networks with controlled network connectivity. Gels, 8 (12) 830 (2022)
 

T. Katashima*, R. Kudo, R. Onishi, M. Naito, S. Nagatoishi, K. Miyata, K. Tsumoto, U. Chung, T. Sakai
Effects of network connectivity on viscoelastic relaxation in transient networks using experimental approach” Front. Soft. Matter., 2, 1059156 (2022)
 

D. Maiti, H. Yu, B. S. Kim, M. Naito, S. Yamashita, H. J. Kim*, K. Miyata*
Rose Bengal Decorated NaYF4:Tb nanoparticles for low dose X-ray-induced photodynamic therapy in cancer cells” ACS Appl. Bio Mater., 5 (11) 5477–5486 (2022)
 

T. Murakami*, S. Hoshi, F. Okamoto, T. Sakai, T. Katashima, M. Naito, T. Oshika
Analysis of the sustained release ability of bevacizumab-loaded tetra-PEG gel. Exp. Eye Res., 223, 109206 (2022)
 

M. Sano, D. Akagi*, M. Naito, K. Hoshina, K. Miyata, K. Kataoka, S. Ishihara
Systemic single administration of anti-inflammatory microRNA 146a-5p loaded in polymeric nanomedicines with active targetability attenuates neointimal hyperplasia by controlling inflammation in injured arteries in a rat model. FASEB., 36 (9) e22486 (2022)
 

H. Panda, M. Suzuki*, M. Naito, R. Saito, H. Wen, A. Uruno, K. Miyata, M. Yamamoto*
Halofuginone micelle nanoparticles eradicate Nrf2-activated lung adenocarcinoma without systemic toxicity. Free Radic. Biol. Med., 187, 92–104 (2022)
 

M. Naito*, Y. Watanuki, K. Toh, J. Yum, B. S. Kim, K. Taniwaki, S. Ogura, H. Ishida, M. Cho, H. Chaya, K. Miyajima, Y. Yamasaki, K. Osada, K. Minegishi, Y. Aoki, K. Miyata*
Size-tunable PEG-grafted copolymers as a polymeric nanoruler for passive targeting muscle tissues. J. Control. Release, 347, 607–614 (2022)
 

T. Katashima*, R. Kudo, M. Naito, S. Nagatoishi, K, Miyata, U. Chung, K. Tsumoto, T. Sakai*
Experimental comparison of bond lifetime and viscoelastic relaxation in transient networks with well-controlled structures. ACS Macro Lett., 11 (6) 753–759 (2022)
 

N. Yoshinaga, S. Uchida*, A. Dirisala, M. Naito, K. Koji, K. Osada, H. Cabral, K. Kataoka*
Bridging mRNA and polycation using RNA oligonucleotide derivatives improves the robustness of polyplex micelles for efficient mRNA delivery. Adv. Healthc. Mater., 11 (9) 2102016 (2022) 
 

M. Ohira, T. Katashima, M. Naito, D. Aoki, Y. Yoshikawa, H. Iwase, S. Takata, K. Miyata, U. Chung, T. Sakai, M. Shibayama, X. Li*
Star-polymer-DNA gels showing highly predictable and tunable mechanical responses. Adv. Mater., 34 (13) 2108818 (2022)
 

J. Yum, B. S. Kim, S. Ogura, R. Kamegawa, M. Naito, Y. Yamasaki, H. J. Kim*, K. Miyata*
Fine-tuning of polyaspartamide derivatives with alicyclic moieties for systemic mRNA delivery. J. Control. Release, 342, 148–156 (2022)
 

H. Chaya, M. Naito, M. Cho, K. Toh, K. Hayashi, S. Fukushima, Y. Yamasaki, K. Kataoka, K. Miyata*
Dynamic stabilization of unit polyion complexes incorporating small interfering RNA by fine-tuning of cationic block length in two-branced poly(ethylene glycol)-b-poly(L-lysine). Biomacromolecules, 23 (1) 388–397 (2022)
 

R. Kamegawa, M. Naito, S. Uchida, H. J. Kim, B. S. Kim, K. Miyata*
Bioinspired silicification of mRNA-loaded polyion complexes for macrophage-targeted mRNA delivery. ACS Appl. Bio Mater., 4 (11) 7790–7799 (2021)
 

W. Yang, T. Miyazaki, P. Chen, T. Hong, M. Naito, Y. Miyahara, A. Matsumoto, K. Kataoka, K, Miyata, H. Cabral*
Block catiomer with flexible cationic segment enhances complexation with siRNA and the delivery performance in vitro. Sci. Technol. Adv. Mater., 22 (1) 850–863 (2021)
 

N. Yoshinaga, M. Naito, Y. Tachihara, E. Boonstra, K. Osada, H. Cabral*, S. Uchida*
PEGylation of mRNA by hybridization of complementary PEG-RNA oligonucleotides stabilizes mRNA without using cationic materials. Pharmaceutics, 13 (6) 800 (2021)
 

C. Wang, K. Kimura, J. Li, J. J. Richardson, M. Naito, K. Miyata, T. Ichiki, H. Ejima*
Polydopamine-mediated surface functionalization of exosomes. ChemNanoMat, 7 (6) 592–595 (2021)
 

Y. Tasaki, M. Suzuki, K. Katsushima, K. Shinjo, K. Iijima, Y. Murofushi, A. Naiki-Ito, K. Hayashi, C. Qiu, A. Takahashi, Y. Tanaka, T. Tanaka, T. Kawaguchi, M. Sugawara, T. Kataoka, M. Naito, K. Miyata, K. Kataoka, T. Noda, W. Gao, H. Kataoka, S. Takahashi, K. Kimura, Y. Kondo*
Cancer-specific targeting of taurine upregulated gene 1 enhances the effects of chemotherapy in pancreatic cancer. Cancer Res., 81 (7) 1654–1666 (2021)
 

M. Naito, H. Chaya, K. Toh, B. S. Kim, K. Hayashi, S. Fukushima, T. Nagata, T. Yokota, K. Kataoka, K. Miyata*
Structural tuning of oligonucleotides for enhanced blood circulation properties of unit polyion complexes prepared from two-branched poly(ethylene glycol)-block-poly(L-lysine). J. Control. Release, 330, 812–820 (2021)
 

N. Yoshinaga, S. Uchida*, A. Dirisala, M. Naito, K. Osada, H. Cabral, K. Kataoka*
mRNA loading into ATP-responsive polyplex micelles with optimal density of phenylboronate ester crosslinking to balance robustness in the biological milieu and intracellular translational efficiency. J. Control. Release, 330, 317–328 (2021)
 

B. S. Kim, M. Naito, H. Chaya, M. Hori, K. Hayashi, H. S. Min, Y. Yi, H. J. Kim, T. Nagata, Y. Anraku, A. Kishimura*, K. Kataoka, K. Miyata*
Noncovalent stabilization of vesicular polyion complexes with chemically modified/single-stranded oligonucleotides and PEG-b-guanidinylated polypeptides for intracavity encapsulation of effector enzymes aimed at cooperative gene knockdown. Biomacomolecules, 21(10) 4365–4376 (2020)
 

B. S. Kim, M. Naito, R. Kamegawa, H. J. Kim, R. Iizuka, T. Funatsu, S. Ueno, T. Ichiki, A. Kishimura, K. Miyata*
Photo-reactive oligodeoxynucleotide-embedded nanovesicles (PROsomes) with switchable stability for efficient cellular uptake and gene knockdown. Chem. Commun., 56 (66) 9477–9480 (2020)
 

Y. Mitobe, K. Ikeda, W. Sato, Y. Kodama, M. Naito, N. Gotoh, K. Miyata, K. Kataoka, H. Sasaki, K. Horie-Inoue, S. Inoue*
Proliferation-associated long noncording RNA, TMPO-AS1, is a potential therapeutic target for triple-negative breast cancer. Cancer Sci., 111 (7) 2440–2450 (2020)
 

B. S. Kim, S. Osawa, J. Yum, M. Naito, K. Miyata*
Installation of thermoswitchable hydrophobic domain into unimer polyion complex for enhanced cellular uptake of siRNA. Bioconjugate Chem., 31 (5) 1320–1326 (2020)
 

H. S. Min, H. J. Kim, M. Naito, S. Ogura, K. Toh, K. Hatyashi, B. S. Kim, S. Fukushima, Y. Anraku, K. Miyata*, K. Kataoka*
Systemic Brain Delivery of Antisense Oligonucleotides across the Blood-Brain Barrier with a Glucose-Installed Polymeric Nanocarrier. Angew. Chem. Int. Ed., 59 (21) 8173–8180 (2020)
 

B. S. Kim, S. Osawa, M. Naito, S. Ogura, R. Kamegawa, H. Ishida, H. J. Kim, S. Uchida, K. Miyata*
A 50 nm-sized micellar assembly of thermoresponsive polymer-antisense oligonucleotide conjugates for enhanced gene knockdown in lung cancer by intratracheal administration. Adv. Therap., 3 (2) 1900123 (2020)
 

B. S. Kim, H. J. Kim, S. Osawa, K. Hayashi, K. Toh, M. Naito, H. S. Min, Y. Yi, I. C. Kwon, K. Kataoka, K. Miyata*
Dually stabilized triblock copolymer micelles with hydrophilic shell and hydrophobic interlayer for systemic antisense oligonucleotide delivery to solid tumor. ACS Biomater. Sci. Eng., 5 (11) 5770–5780 (2019)
 

N. Yoshinaga, E. Cho, K. Koji, Y. Mochida, M. Naito, K. Osada, K. Kataoka, H. Cabral*, S. Uchida*
Bundling mRNA strands to prepare nanoassemblies with enhanced RNase stability for in vivo delivery. Angew. Chem. Int. Ed., 58 (33) 11360–11363 (2019)
 

N. Yoshinaga, S. Uchida*, M. Naito, K. Osada, H. Cabral, K. Kataoka*
Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection. Biomaterials, 197, 255–267 (2019)
 

Y. Yi, H. J. Kim, M. Zheng, P. Mi, M. Naito, B. S. Kim, H. S. Min, K. Hayashi, F. Perche, K. Toh, X. Liu, Y. Mochida, H. Kinoh, H. Cabral, K. Miyata*, K. Kataoka*
Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. J. Control. Release, 295, 268–277 (2019)
 

B. S. Kim, S. Chuanoi, T. Suma, Y. Anraku, K. Hayashi, M. Naito, H. J. Kim, I. C. Kwon, K. Miyata*, A. Kishimura*, K. Kataoka*
Self-assembly of siRNA/PEG-b-catiomer at integer molar ratio into 100 nm-sized vesicular polyion complexes (siRNAsomes) for RNAi and codelivery of cargo macromolecules. J. Am. Chem. Soc., 141(8) 3699–3709 (2019)
 

M. Naito, Y. Otsu, R. Kamegawa, K. Hayashi, S. Uchida, H. J. Kim, K. Miyata*
Tunable nonenzymatic degradability of N-substituted polyaspartamide main chain by amine protonation and alkyl spacer length in side chains for enhanced messenger RNA transfection efficiency. Sci. Technol. Adv. Mater., 20(1) 105–115 (2019)
 

H. S. Min, H. K. Kim, J. Y. Ahn, M. Naito, K. Hayashi, K. Toh, B. S. Kim, Y. Matsumoto, I. C. Kwon, K. Miyata*, K. Kataoka*
Tuned density of anti-Tissue Factor Antibody fragment onto siRNA-loaded polyion complex micelles for optimizing targetability into pancreatic cancer cells. Biomacromolecules, 19(6) 2320–2329 (2018)
 

A-H. Ranneh, H. Takemoto*, S. Sakuma, A. Awaad, T. Nomoto, Y. Mochida, M. Matsui, K. Tomoda, M. Naito, N. Nishiyama*
An ethylenediamine-based betaine structure switches the neutral net charge of polyzwitterion into cationic at tumorous pH for effective tumor accumulation of the coated nanomaterials. Angew. Chem. Int. Ed., 57(18) 5057–5061 (2018)
 

M. Naito, N. Yoshinaga, T. Ishii, A. Matsumoto, Y. Miyahara, K. Miyata*, K. Kataoka*
Enhanced intracellular delivery of siRNA by controlling ATP-responsivity of phenylboronic acid-functionalized polyion complex micelles. Macromol. Biosci., 18(1) 1700357 (2018)
 

N. Yoshinaga, T. Ishii, M. Naito, T. Endo, S. Uchida, H. Cabral, K. Osada*, K. Kataoka*
Polyplex micelles with phenylboronate/gluconamide cross-linking in the core exerting promoted gene transfection through spatiotemporal responsivity to intracellular pH and ATP concentration. J. Am. Chem. Soc., 139(51) 18567–18575 (2017)
 

M. Naito, R. Azuma, H. Takemoto, M. Hori, N. Yoshinaga, S. Osawa, R. Kamegawa, H. J. Kim, T. Ishii, N. Nishiyama, K. Miyata*, K. Kataoka*
Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA delivery. J. Biomater. Sci. Polym. Ed., 28(Issue10-12) 1109-1123 (2017)
 

Y. Yi, H. J. Kim, P. Mi, M. Zheng, H. Takemoto, K. Toh, B. S. Kim, K. Hayashi, M. Naito, Y. Matsumoto, K. Miyata*, K. Kataoka*
Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticles. J. Control. Release, 244 PartB, 247–256 (2016)
 

K. Katsushima, A. Natsume, F. Ohta, K. Shinjo, A. Hatanaka, N. Ichimura, S. Sato, S. Takahashi, H. Kimura, Y. Totoki, T. Shibata, M. Naito, H. J. Kim, K. Miyata, K. Kataoka, Y. Kondo*
Targeting the notch-regulated non-coding RNA TUG1 for glioma treatment. Nat. Commun., 7 13616 (2016)
 

H. Nishida, Y. Matsumoto, K. Kawana*, R. J. Christie, M. Naito, B. S. Kim, K. Toh, H. S. Min, Y. Yi, Y. Matsumoto, H. J. Kim, K. Miyata*, A. Taguchi, K. Tomio, A. Yamashita, T. Inoue, H. Nakamura, A. Fujimoto, M. Sato, M. Yoshida, K. Adachi, T. Arimoto, O. Wada-Hiraike, K. Oda, T. Nagamatsu, N. Nishiyama, K. Kataoka*, Y. Osuga, T. Fujii
Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenes. J. Control. Release, 231 29–37 (2016)
 

T. Ishii, K. Miyata. Y. Anraku, M. Naito, Y. Yi, T. Jinbo, S. Takae, Y. Fukusato, M. Hori, K. Osada, K. Kataoka*
Enhanced target recognition of nanoparticles by cocktail PEGylation with chains of varying lengths. Chem. Commun., 52 (7) 1517–1519 (2016)
 

M. Tangsangasaksri, H. Takemoto, M. Naito, Y. Maeda, D. Sueyoshi, H. J. Kim, Y. Miura, J. Y. Ahn, R. Azuma, N. Nishiyama, K. Miyata*, K. Kataoka*
siRNA-loaded polyion complex micelle decorated with charge-conversional polymer tuned to undergo stepwise response to intra-tumoral and intra-endosomal pHs for exerting enhanced RNAi efficacy. Biomacromol., 17(1) 246–255 (2015)
 

H. Gao, H. Takemoto, Q. Chen, M. Naito, H. Uchida, X. Liu, K. Miyata*, K. Kataoka*
Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery. Chem. Commun., 51(15) 3158–3161 (2015)
 

Y. Oe, R. J. Christie, M. Naito, S. A. Low, S. Fukushima, K. Toh, Y. Miura, Y. Matsumoto, N. Nishiyama, K. Miyata*, K. Kataoka*
Actively-targeted polyion complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors. Biomaterials, 35 (27) 7887–7895 (2014)
 

M. Naito, T. Ishii, A. Matsumoto, K. Miyata, Y. Miyahara, K. Kataoka*
A phenylboronate-functionalized polyion complex micelle for ATP-triggered release of siRNA. Angew. Chem. Int. Ed., 51(43) 10751–10755 (2012)